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F1 scores of detecting sample-specific SNVs and INDELs are shown with two dashed lines point to 5 and 10% VAFs. Performance is shown in seven VAF bins (<1, 1–2, 2–3, 3–4, 4–10, 10–15, 15–25 and ≥25%). Dashed line with dots depicts the theoretical upper limit for F1 scores.
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