Line Plot from Scientific Research

Sensitivity, precision, F1 score, AUPRC and the false positive rate (log 10 FP/1Mbp) in different VAF bins categories are shown. The dashed line with dots depicts the theoretical upper limit for sensitivity and F1 score by depletion of mutant alleles in sequencing data at low VAFs ( Supplementary Notes ). The two vertical lines with gray dashes refer to VAFs of 5 and 10%. The y axis of log 10 (FP rate) is shown as a square root. b , SNV detection performance of six applied approaches in the eight VAF bins (less than 1, 1–2, 2–3, 3–4, 4–7.5, 7.5–9.6, 9.6–25 and >=25%) with 1,100x data.

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