Bar Plot from Scientific Research

Secreted progesterone levels after mini-DREAM-transduced HEK293T cells were transfected with the indicated gRNA array or a nontargeting gRNA control plasmid. All samples were processed for qPCR or ELISA at 72 h post-transfection. Data are the result of 4 biological replicates for b , c , e , f , j , m and n , and 3 or 4 biological replicates for h . See the source data for more information. Data are presented as mean s.e.m. P values were determined using unpaired two-sided t -test. BH, bridge helix; eN, engineered NRF2; M, MRTF-A; PI, PAM-interacting domain; REC, recognition lobe; S, STAT1.

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