Scatter Plot from Scientific Research

RNA-seq data generated after the DREAM or SAM systems were targeted to the HBG1 / HBG2 promoter using 4 pooled gRNAs. mRNAs identified as significantly differentially expressed (fold change >2 or <-2 and FDR < 0.05) are shown as red dots. In the top MA plot (CRISPR-DREAM), mRNAs corresponding to HBG1 / HBG2 (target genes) are highlighted in light blue. In the bottom MA plot (SAM system), mRNAs corresponding to HBG1 / HBG2 (target genes) are highlighted in light gray. mRNAs encoding human components of the MSN or SAM systems shown were also significantly differentially expressed (fold change >2 and FDR < 0.05) and are shown in red.

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