Illustration from Scientific Research

Upper panel, dCas9-VPR size and the split site used for REVeRT. Lower panel, REVeRT vector cassettes expressing split dCas9-VPR and three sgRNAs (g1–g3) targeting the promoter region of Myo7b. Titer-matched dual REVeRT AAV8(Y733F) vectors were injected via different routes of administration shown in (c, f, h).

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