Line Plot from Scientific Research

Total number of mutations per patient per megabase in the LUAD cohort of the AACR Project GENIE database. Analysis was restricted to samples sequenced with the MSK-IMPACT468 panel. Missense, stop, and frameshift variants were included, and any mutations predicted by Polyphen as benign or by Sift as tolerated were excluded. Patient sample sizes were: KRAS n = 1134, EGFR n = 935, and BRAF n = 135. The same patients were used for all following human analysis panels.

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