Relative size of the tumor at the indicated percentiles (see legend in ( A , B )) of the tumor size distributions for barcoded Lenti-sgRNA/Cre vectors targeting Kras WT across multiple arms of our main experiment and repeat studies in G12C;Cas9 and G12D;Cas9 mice. The significance of oncogene differences at the 95th percentile were calculated by combining the study groups for each oncogene using inverse variance weighting and comparing the resulting means and variances under a normally distributed null. Bonferroni-corrected, one-sided P values are shown for significant genes. For each study group from left to right along the x axes, data include n = 10, n = 10, n = 18, n = 13, n = 35, n = 23, and n = 33 biologically independent animals. Note that the two study groups from repeat studies in G12D;Cas9 correspond to Group 8 and Group 3 in Supplementary Fig. 5 .
