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Presynaptic inhibition by SDGs via GABA signaling. Noxious stimuli first activate the peripheral C4da neurons, followed by subsequent activation of downstream secondary neurons that trigger the onset of larval rolling. During this process of nociceptive information relay, SDGs become activated and in turn send GABAergic inhibitory inputs to C4da neurons via GABA B -Rs. This SDGs-mediated negative feedback induces rolling termination with a time lag, which enables behavior transition for efficient escape from danger.

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