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An illustration of the molecular model of UBC tumorigenesis, discovered by the TimeAx-based analysis, based on the increasing gene module. The illustration includes the association of known hallmarks of cancer with disease pseudotime (top) and the suggested mitotic kinetochore- spindle microtubules (MT) interaction (middle), which is also presented as boxplots of differential expression of its subunits (bottom; n = 40 biologically independent samples, boxes represent the 25th, 50th, and 75th percentiles; whiskers show maxima and minima). G protein-coupled receptors (GPCRs). We thank Yuval Abraham for his contribution in the design and creation of (E).

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