Protein Structure from Scientific Research

Superimposition of SLC9C1 structures in detergent without cAMP (grey) and with cAMP (coloured as in a). The binding of cAMP to the CNBD probably detaches the domain from S4 and from ICH5, which propagates with the displacement of ICH3, ICH4 and ICH5 as also shown in Extended Data Fig. 10b. The change in the position of the ICHs has altered the positioning of the VSD. Inset: magnified view showing the anti-clockwise movement of the S1–S3 helices when comparing the SLC9C1 structures obtained with (coloured) and without (grey) cAMP addition.

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