Protein Structure from Scientific Research

VSD of SLC9C1 with S3 omitted to highlight key residues (yellow sticks) (left). The occlusion-forming Tyr743 in S2 and the negatively charged residue Glu746, together with Asp767, make up the conserved charge transfer centre 43. S4 is in the up-state and gating-charge residues Arg803 (R2) to Lys815 (K6) extend from the 3 10 helix. The gating-charge residues Arg803 (R2), Arg806 (R3) and Arg809 (R4) are positioned above the charge transfer centre, and probably account for the three measured gating-charges 2. Right, as described for the left image, with key residues of SLC9C1 (yellow sticks) and VSD IV of human NaV1.7 (pink sticks) labelled.

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