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A. The location of the mutations in p53. The most frequently mutated hotspot codons are R175, G245, R248, R249, R273, R282. B. Bar graph represents the mutation frequency in different domains of p53. C. Schematic representation of the p53 protein indicating the DNA binding domain (DBD), oligomerization domain (OD) and the N-terminal transactivation domain (TAD).

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