Bar Plot from Scientific Research

Viability effect of CRISPRi-mediated PELO knockdown (KD) normalized to average of negative controls (grey dashed line; empty vector and/or gRNA Ch2-2) and positive controls (orange dotted line; gRNA for SF3B1 and/or POLR2D ) for 9p21.3 + or short deletion/MSS ( n = 4), 9p21.3 −/− /MSS ( n = 3) and 9p21.3 + /MSI-H cell lines ( n = 3). Data are mean ± s.e.m. of biological replicates: n = 6 for all cell lines except KP4 and GB1, for which n = 7, and IGROV-1, for which n = 3. Significance was calculated as follows: left-tailed Students t -test. Representative data are shown from two experiments.

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