Numbers of CB and VWA domain-containing genes (histogram graph in a) as well as Pif, ancestral Pif, and LamG3 genes (bubble chart in b) were determined in 19 metazoan genomes (Aam, Amphibalanus amphitrite ; Adi, Acropora digitifera ; Apl, Acanthaster planci ; Bfl, Branchiostoma floridae ; Cin, Ciona intestinalis ; Cni, Crassostrea nippona ; Dme, Drosophila melanogaster ; Dre, Danio rerio ; Hsa, Homo sapiens ; Lan, Lingula anatina ; Lgi, Lottia gigantea ; Mco, Mytilus coruscus ; Mye, Mizuhopecten yessoensis ; Mme, Mercenaria mercenaria ; Npo, Nautilus pompilius ; Obi, Octopus bimaculoides ; Pau; Phoronis australis ; Pec, Paraescarpia echinospica ; Pfu, Pinctada fucata ). The schematized phylogenetic tree below the bubble chart indicates the evolutionary relationships among species