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Biological aging across the intervention groups in subgroups of health status, men only. Forest plot showing the mean and SE of 18-month change in Li mAge. Data presented as mean and SE across health status and diet subgroups. The presence of DM was defined for participants with baseline fasting plasma glucose levels >= 126 mg/dL or hemoglobin-A1c levels >= 6.5% or if regularly treated with oral antihyperglycemic medications or exogenous insulin. Liver status was based on MRI-measured live fat, as published before [ 26 ], with a cutoff > 5% defining fatty liver. Interactions presented are between the health status and intervention. BMI, body mass index; DM, diabetes mellitus; MS, metabolic syndrome

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