In each circular Manhattan plot, the outermost circle shows the cross-trait meta-analysis results between gallstone disease and coronary artery disease; from the periphery to the center, each circle shows the GWAS results on gallstone disease and cardiovascular diseases, respectively. Light blue indicates variants with genome-wide significance (P < 5 x 10 –8) while dark blue indicates variants with P ≥ 5 x 10 –8. According to their single-trait and cross-trait characteristics, SNPs are divided into two different types named “Known associated SNP” and “Novel shared SNP”,which are presented in grey and red, respectively. RSIDs of them are listed.
