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Diagram for the amelioration of gut metabolite 3-Hydroxyphenylacetic acid on the aging-related spermatogenic dysfunction. The altered GM abundance in intestine were closely related to the changed gut bacteria-derived metabolite, 3-Hydroxyphenylacetic acid (3-HPAA). 3-HPAA promotes GPX4-mediated reduction of intracellular phospholipid hydroperoxides (PL-OOH) and 3-HPAA-related metabolic pathway may alleviate the impaired spermatogenesis of aging mice through regulation of ferroptosis

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