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Schematic diagram showing experimental design. The date of constructing mixed hyperlipidemia model was defined as the baseline, on which golden hamsters were fed with high-fat diet. Lovastatin, lovastatin plus probiotics were administered daily from week 8 to week 12 (Lov group, L+A5 group, L+C3 group, and L+LcS group), and the MO group was replaced by carboxymethyl cellulose. The golden hamsters were killed in the 12th week. At the 8th week and the 12th week, fecal samples were collected for shotgun metagenomic sequencing, and serum was collected for blood index detection. At the 12th week, liver tissues were collected for the determination of liver transcriptome and liver tissue sections, and intestinal contents were collected for the determination of SCFAs

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