Table Image from Scientific Research

The number and classification of variants discussed at the MDT meetings and returned to the treating clinician after the MDT meeting. Classifications: LP—likely pathogenic; P—pathogenic; VUS—variant of uncertain significance; VUS:A—available evidence is highly suggestive that the VUS variant is disease-causing; VUS:B—available evidence is insufficient to classify the VUS variant as either disease-causing or benign; and VUS:C—available evidence is highly suggestive that the VUS variant is likely benign. ^Two pathogenic PALB2 variants known to be common within the Australian population were reported directly to the relevant Familial Cancer Centre without a formal MDT meeting.

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