Absolute numbers of donor ( c ) and host ( d ) HSCs in aged recipients treated with CD45-SAP with or without G-CSF/AMD3100. In ( d ), HSC numbers in age-matched untreated controls were assessed for comparison ( n = 5). In ( b–d ), gray, red, and dark gray circles represent CD45-SAP-, CD45-SAP/G-CSF/AMD3100-treated and untreated groups, respectively. In ( b–d ), error bars denote mean ± SEM. Statistical significance was determined by unpaired two-sided t test with Welch correction in ( b–c ) and ( e ), one-way ANOVA with a Tukey test in ( d ), two-sided Wilcoxon matched-pairs signed rank test in ( g ) and paired two-sided t test in ( i ). Source data are provided as a Source Data file.
