Schematic representation of the concept of the chemically fuelled dynamic combinatorial library and the role of the template. Oligomers interact with the template. The six-atom repeating backbone unit of DNA and the oligomers (highlighted with grey shading) match. The molecular structures of the DNA template (dA) 10 , thymine-labelled monomer T and its oligomers, fuel 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide (EDC) and waste 1-ethyl-3-(3-(dimethylamino)propyl)urea (EDU) are shown. The reactive molecule sites, recognition motifs (for example, thymine) and complete molecular structures are colour-coded as follows: monomer acid (blue), thymine (red), adenine (green), oligomer anhydride (orange), fuel (purple) and waste (black). The pictograms for thymine oligomers are coloured red and the DNA template is coloured green.
