Whole exome analysis of 428,719 individuals from UK Biobank dataset analyzing association betweenGPR75variants and body fat identified 135 individuals (female:n= 72; male:n= 63) carrying high-confidence (HC) protein-truncating variants (PTVs) inGPR75. Distribution plot shows percentage body fat score (Zscore) calculated by sex against HC PTV mutations. An association between HC PTVGPR75mutations and lower fat percentage was observed overall (combined: Bolt-lmm Infp= 0.0016, beta = -1.5906, SE = 0.5038, STAAR-Op= 0.0027) and when examining males (blue line; STAAR-Op= 0.0364, Bolt-lmm Infp= 0.011, beta = -1.7294, SE = 0.6760) and females (red line; Bolt-lmm Infp= 0.016, beta = -1.7998, SE = 0.7503, STAAR-Op= 0.0363) separately.
